This study builds on the assumption that any change in the structure of the international system in the foreseeable future cannot be immediately ascribed to the outbreak of the Covid-19 pandemic. However, even if the pandemic is purely incidental and unable to change the existing distribution of power, this does not mean it has not introduced a dialogue within International Relations on the impact of epidemics on the structure of the international system, and their ability to intensify some essential - economic, social, and political - factors that contribute to international system change. International power balances before the outbreak of the pandemic indicate the beginning of change of the international system, as if it has been moving towards multipolarity, particularly with many rising powers, such as China, Russia and the European Union, whose international interests challenge those of the US, especially as the latter persistently impedes any rise of rival powers in the foreseeable future.