A chemical weapons attack by the Syrian regime on August 21, 2013, led to a massacre of civilians in the towns of East Ghouta and West Ghouta on the outskirts of Damascus and marked a turning point in the Syrian conflict. US President Barack Obama had previously undertaken to respond militarily if such an attack took place, provided that Congress would support such a decision. Such a direct US military intervention remained likely despite opposition among the American public and within Congress itself, up to and until a Russian proposal, quickly accepted by the Assad regime in Damascus, which would place all of Syria’s chemical weapons under international supervision before they were destroyed by Moscow. This paper examines how the Obama White House dealt with the use of chemical weapons by the Syrian regime. The paper also deals with declining international interest in a diplomatic resolution to the Syrian crisis, with the world community now shifting its focus from punishing the Assad regime to accepting the destruction of those weapons.