This paper monitors the post-2007 trends of US foreign policy towards the Gaza Strip. This paper's discussion first examines the general framework of the US approach to the Arab-Israeli conflict before discussing the quandary posed by the Gaza Strip to that framework. The paper then focuses on the role played by President George W. Bush's administration in creating the impasse over Gaza, deconstructs the efforts to overthrow Hamas, and tracks the attempts to isolate and marginalize the Gaza Strip. Finally, it analyses the status of the Gaza Strip in the respective administrations of US presidents Barack Obama and Donald Trump. The paper concludes that the Gaza Strip represents a predicament to both the US and Israel, to a large extent the outcome of flawed and biased US policies as well as symptomatic of the Zionist project in occupied Palestine; an outcome that cannot justify the crushing crisis caused by the official Egyptian blockade on the Gaza Strip.