An agreement signed by the Russian Foreign Minister and his US counterpart in Moscow has taken observers by surprise due to its timing and the surrounding circumstances. The agreement in Moscow was the natural culmination of a series of events impacting the situation in Syria, including changes to the composition of Barack Obama’s Administration and an overall shift in American attitudes towards the Arab Spring. This has presaged a change in American vision towards its interests in the wider Middle East region and Washington’s relations with both regional powers and global players with influence on the Syrian conflict. Finally, the agreement can be regarded as an expression of American uncertainty, as well as the Obama Administration’s inability to formulate a coherent policy towards Syria two years into the revolution.