Following the transformations in the Levant’s regional system since the beginning of World War II to the rise of the Islamic State group in Iraq and Syria, this paper examines the new context of the region with regard to Washington’s resumption of direct military intervention. It finds that the Levant – as a soft area easily subject to geopolitical influences – has always been subject to changes based on shifts in world order, from the Cold War, followed by unipolarity, to the relative decline of US power. Thus, while the main actors of the Levant’s regional system were Arabs during the Cold War, the region has become a battleground for non-Arab parties – namely Turkey and Iran – following the invasion or Iraq and the eruption of the Arab Spring revolutions.